MORRIS BERK, M.D.
BERK M. RHINOCEREBRAL PHYCOMYCOSIS IN DIABETICS WITHOUT ACIDOSIS. Ann Intern Med. 1967;67:907. doi: 10.7326/0003-4819-67-4-907_1
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Published: Ann Intern Med. 1967;67(4):907.
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To the Editor: In the April (1967) issue of the ANNALS, two cases of rhinocerebral phycomycosis in association with diabetic ketoacidosis are reported. The article embodies a table of previously reported cases (16) of the fungal disease (all treated with amphotericin B), including a case reported by my coauthors and me. All such listed cases were "associated" with an acidotic state (diabetic, except for one secondary to diarrhea). The implication appears to be that an acidotic "soil" is a necessity for the invasiveness of this fungus (which is a saprophyte and often a human contaminant).
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