GERALD T. MULLIN, M.D.; ERSKINE M. CAPERTON, M.D.; STEPHEN R. CRESPIN, M.D.; RALPH C. WILLIAMS, M.D.
MULLIN GT, CAPERTON EM, CRESPIN SR, WILLIAMS RC. Arthritis and Skin Lesions Resembling Erythema Nodosum in Pancreatic Disease. Ann Intern Med. 1968;68:75-87. doi: 10.7326/0003-4819-68-1-75
Download citation file:
Published: Ann Intern Med. 1968;68(1):75-87.
The clinical picture of subcutaneous fat necrosis, acute synovitis, and subcutaneous nodules present in some patients with pancreatitis or carcinoma of the pancreas may mimic erythema nodosum. Predominant severe polyarthritis secondary to periarticular fat necrosis or relatively frequent great-toe involvement may make this clinical symptom complex difficult to distinguish from a generalized connective tissue disorder or gouty arthritis. Eosinophilia of 5 to 21% has been noted frequently when subcutaneous fat necrosis accompanies carcinoma of the pancreas. Definitive diagnosis of subcutaneous or periarticular fat necrosis by skin or soft tissue biopsy has been frequently recorded among the 36 patients documented in the literature to date. Unusual subcutaneous nodules often appearing in successive crops and exhibiting a diffuse distribution (buttocks, trunk, back, and even scalp) associated with signs of active synovitis should alert the clinician to the possibility of occult or unconsidered pancreatic disease.
Learn more about subscription options.
Register Now for a free account.
Emergency Medicine, Gastroenterology/Hepatology, Pancreatic Disease, Rheumatology.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only