CHARLES C. DOUGLASS, M.D.; MARY S. MCCALL, B.S.; EUGENE P. FRENKEL, M.D., F.A.C.P.
A patient with severe cirrhosis and hemolytic anemia associated with marked acanthocytosis is described. Wet preparations revealed the acanthocytes to be rigid and nonpliable without rouleaux formation. Numerous in vitro studies failed to demonstrate any additional abnormalities.51Cr-labeled red cell survival studies demonstrated a markedly shortened survival both in the patient and in a normal recipient, while the patient's cells survived normally in an asplenic individual. The present case, and previous findings in studies of the acanthocytes associated with cirrhosis, demonstrate that they are significantly different in character from those found in a-beta-lipoproteinemia. It is suggested that the shortened life-span of the acanthocytes in our patient may be due to their nonpliable character, leading to sequestration in the spleen.
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DOUGLASS CC, MCCALL MS, FRENKEL EP. The Acanthocyte in Cirrhosis with Hemolytic Anemia. Ann Intern Med. 1968;68:390-397. doi: 10.7326/0003-4819-68-2-390
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Published: Ann Intern Med. 1968;68(2):390-397.
Gastroenterology/Hepatology, Hematology/Oncology, Liver Disease, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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