DIETER BURCKHARDT, M.D.; CESAR A. VERA, M.D.; JOHN S. LADUE, M.D., PH.D., F.A.C.P.
BURCKHARDT D, VERA CA, LADUE JS. Effect of Digitalis on Urinary Pituitary Gonadotrophin Excretion: A Study in Postmenopausal Women. Ann Intern Med. 1968;68:1069-1071. doi: 10.7326/0003-4819-68-5-1069
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Published: Ann Intern Med. 1968;68(5):1069-1071.
In 20 postmenopausal women 51 to 70 years old receiving maintenance dosages of digitalis, the follicle-stimulating hormone (FSH) levels were significantly lower ( P < 0.01 ) than in 20 control patients of the same age group. This is presumably due to an estrogen-like activity of digitalis that inhibits FSH formation as natural estrogens do.
The significance of FSH excretion and Papanicolaou vaginal smear interpretation must be modified in the postmenopausal patients taking cardiac glycosides.
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Cardiology, Hospital Medicine.
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