Robert F. Knouss, B.S.; Robert E. Gebhardt, B.A.; Per T. Thyrum, Ph.D.; Robert J. Luchi, M.D., F.A.C.P.; James J. Morris, M.D.
This content is PDF only. Please click on the PDF icon to access.
Quinidine toxicity may develop unexpectedly when the urine becomes alkaline in disease or during alkalinizing therapy. Urinary excretion of quinine, the optical isomer of quinidine, is known to be retarded by urine alkalinization. These observations prompted study of renal excretion of quinidine as a function of urine pH. Four subjects were given 0.2 g of quinidine sulfate orally every 6 hr. After a 5-day "loading period" urine quinidine and pH were determined for each voiding during 4 days of aciduria and 4 days of alkaluria (acetazolamide and sodium bicarbonate). The results indicated that urine excretion of quinidine varied inversely with
Learn more about subscription options.
Register Now for a free account.
Knouss RF, Gebhardt RE, Thyrum PT, Luchi RJ, Morris JJ. Variation in Quinidine Excretion with Changing Urine pH.. Ann Intern Med. 1968;68:1157. doi: 10.7326/0003-4819-68-5-1157_2
Download citation file:
Published: Ann Intern Med. 1968;68(5):1157.
Cardiology, Nephrology, Rhythm Disorders and Devices.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only