Bertha A. Bouroncle, M.D., F.A.C.P.; Charles A. Doan, M.D., M.A.C.P.
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Splenectomy and corticosteroids are recognized therapeutic measures for the treatment of idiopathic thrombocytopenic purpura. In our overall evaluation of 271 patients, previously reported, 7.7% were refractory to both methods of therapy.
During the past 3½ years we have treated 16 of these cases of refractory idiopathic thrombocytopenic purpura for long-term therapy with the immunosuppressive drug azathioprine (Immuran®).
Doses of 1.2 to 4.2 mg/kg body weight (50 to 250 mg) daily, which were effective in obtaining a remission, have practically no toxic effects. Only two patients had moderate degree of leukopenia, which was rapidly reversible. The danger of producing a general
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Bouroncle BA, Doan CA. Treatment of Refractory Idiopathic Thromboctopenic Purpura.. Ann Intern Med. 1968;68:1164. doi: 10.7326/0003-4819-68-5-1164_2
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Published: Ann Intern Med. 1968;68(5):1164.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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