Cyril A. Clarke, F.R.C.P.
Clarke CA. Prevention of Rh-Hemolytic Disease.. Ann Intern Med. 1968;68:1166. doi: 10.7326/0003-4819-68-5-1166_3
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Published: Ann Intern Med. 1968;68(5):1166.
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In the past few years, principally in the United Kingdom, the United States, and Germany, numerous papers have appeared demonstrating that it is possible usually to prevent Rh isoimmunization by giving incomplete anti-D (Rh°) antibody (as anti-D gamma globulin) to previously unsensitized women within 72 hr of the birth of an Rh-positive ABO compatible baby. The passive antibody probably protects against immunization either by coating and thereby inactivating Rh-positive fetal cells that have leaked across the placenta at or near delivery or by a central feedback mechanism by which the passive antibody inhibits the activity of the antibody-producing cells.
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