William E. Miller, M.D.; Sharad D. Deodhar, M.D.; Ray W. Gifford, M.D., F.A.C.P.; David C. Humphrey, M.D., F.A.C.P.; Donald G. Vidt, M.D.
Miller WE, Deodhar SD, Gifford RW, Humphrey DC, Vidt DG. Selectivity Index as a Guide to Treatment in Heavy Proteinuria.. Ann Intern Med. 1968;68:1182. doi: 10.7326/0003-4819-68-5-1182_2
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Published: Ann Intern Med. 1968;68(5):1182.
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Cameron and blandford recently proposed a simplified method for assessing the selectivity of proteinuria in patients with nephrotic syndrome. The ratio of the clearance immunoglobulin (IgG) to the clearance of transferrin correlated well with response to immunosuppressive therapy.
The selectivity indexes of 29 patients (25 adults, 4 children) with heavy proteinuria (> 2.0 g/day) were determined before the beginning of immuno-suppressive therapy. Histologic correlation from renal biopsy specimens was available in all cases.
Sixteen patients had selectivity indexes of 0.2 or less. Eleven of these patients responded favorably to immunosuppressive treatment, three with a complete remission. Selectivity indexes of greater
Nephrology, Urological Disorders.
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