R. W. E. Watts, M.D., F.R.C.P.
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There is a continuous high urinary oxalate excretion in primary hyperoxaluria. Glycine is a metabolic precursor of oxalate, and the relative importance of the alternative metabolic pathways from glycine to oxalate have been studied in vivo using (1-13C) glycine and (2-13C) glycine. The results indicate that the main metabolic sequence is glycine → glyoxylate oxalate but that there is also a subsidiary contribution through the sequence glycine → serine → ethanolamine → glycolic aldehyde → glycolate glyoxylate → oxalate.
The metabolism of glyoxylate has been investigated in vitro in some human tissues. Kidney tissue from two patients with primary hyperoxaluria
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Watts RWE. Metabolic Studies on Primary Hyperoxaluria.. Ann Intern Med. 1968;68:1191. doi: 10.7326/0003-4819-68-5-1191_1
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Published: Ann Intern Med. 1968;68(5):1191.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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