GEORGE SAROSI, M.D.; RICHARD P. DOE, M.D., PH.D.
SAROSI G, DOE RP. Familial Occurrence of Parathyroid Adenomas, Pheochromocytoma, and Medullary Carcinoma of the Thyroid with Amyloid Stroma (Sipple's Syndrome). Ann Intern Med. 1968;68:1305-1309. doi: 10.7326/0003-4819-68-6-1305
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Published: Ann Intern Med. 1968;68(6):1305-1309.
An additional family is reported with the association of bilateral pheochromocytoma, bilateral medullary carcinoma of the thyroid with amyloid stroma, and bilateral parathyroid adenomas. The propositus also had a ganglioneuroma in the right adrenal area and had Parkinson's disease. In the patients with pheochromocytoma and parathyroid adenoma, a thyroid carcinoma had been uniformly present (100%). In addition, when parathyroid adenoma and pheochromocytoma are present, the likelihood of bilateral pheochromocytoma (84%) and multiple parathyroid adenomas (42%) should be borne in mind by the surgeon.
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Endocrine and Metabolism, Hematology/Oncology, Endocrine Cancer.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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