GEORGE SAROSI, M.D.; RICHARD P. DOE, M.D., PH.D.
An additional family is reported with the association of bilateral pheochromocytoma, bilateral medullary carcinoma of the thyroid with amyloid stroma, and bilateral parathyroid adenomas. The propositus also had a ganglioneuroma in the right adrenal area and had Parkinson's disease. In the patients with pheochromocytoma and parathyroid adenoma, a thyroid carcinoma had been uniformly present (100%). In addition, when parathyroid adenoma and pheochromocytoma are present, the likelihood of bilateral pheochromocytoma (84%) and multiple parathyroid adenomas (42%) should be borne in mind by the surgeon.
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SAROSI G, DOE RP. Familial Occurrence of Parathyroid Adenomas, Pheochromocytoma, and Medullary Carcinoma of the Thyroid with Amyloid Stroma (Sipple's Syndrome). Ann Intern Med. 1968;68:1305–1309. doi: 10.7326/0003-4819-68-6-1305
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Published: Ann Intern Med. 1968;68(6):1305-1309.
Endocrine and Metabolism, Endocrine Cancer, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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