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Blood platelets are known to undergo striking structural alterations as they function in both normal hemostasis and pathologic thrombosis. In this monograph, Dr. Schulz has presented ultrastructural features of thrombocytopoiesis, the normal platelet, and disease-related modifications in platelet fine-structure.
The discovery of blood platelets and their production by bone marrow megakaryocytes is discussed, with emphasis on the works of Bizzozero and Wright. Following the historical introduction, a more detailed ultrastructural description of megakaryocyte morphology as related to platelet production, granulopoiesis, and pathology is presented. Finally, the stages of thrombosis are discussed with divisions based on platelet accumulation and ultrastructural changes,
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Thrombocyten und Thrombose im Elektronenmikroskopischen Bild.. Ann Intern Med. 1968;69:183. doi: 10.7326/0003-4819-69-1-183_2
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Published: Ann Intern Med. 1968;69(1):183.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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