EDWARD C. LYNCH, M.D., F.A.C.P.; JOHN G. MCKECHNIE, M.D.; CLARENCE P. ALFREY JR., M.D., F.A.C.P.
The unique occurrence of severe pancytopenia and splenomegaly in a young woman with brucellosis is reported. Hemoglobin was 6.2 g/100 ml; total leukocyte count, 2,200/mm3; platelet count, 12,000/mm3; and reticulocyte percentage, 4.3. Six of 8 blood cultures grew Brucella abortus. The hematological abnormalities and the splenic enlargement disappeared after treatment with tetracycline and streptomycin. Hypersplenism was the most likely mechanism of the anemia, granulocytopenia, and thrombocytopenia. The direct Coombs' reaction was initially positive and became negative after effective treatment of the brucellosis. The positive antiglobulin reaction in this patient may have resulted from either the brucellosis or from prior transfusions.
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LYNCH EC, MCKECHNIE JG, ALFREY CP. Brucellosis with Pancytopenia. Ann Intern Med. 1968;69:319–322. doi: 10.7326/0003-4819-69-2-319
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Published: Ann Intern Med. 1968;69(2):319-322.
Hematology/Oncology, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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