WILBERT S. ARONOW, M.D.; MARVIN A. KAPLAN, M.D.; DESIDERIO JACOB, M.D.
Ten patients with classical angina pectoris due to coronary artery disease were exercised in an upright position with a fixed exercise load on a bicycle ergometer until they developed the first manifestation of angina pectoris. They each performed this exercise four times in a nonsmoking state and four times after smoking a cigarette of high nicotine content for 5 min. All subjects developed angina sooner if they smoked before exercising. The average percent of shortening of the exercise period before angina developed in the smoking state as compared with the nonsmoking state was 24. All patients developed an increase in the modified tension-time index after smoking. This increase represents an increase in myocardial oxygen consumption. After exercise, patients with diseased coronary arteries who smoke may not meet the increased demand for myocardial oxygen and, therefore, may develop angina sooner.
Learn more about subscription options.
Register Now for a free account.
ARONOW WS, KAPLAN MA, JACOB D. Tobacco: A Precipitating Factor in Angina Pectoris. Ann Intern Med. 1968;69:529-536. doi: 10.7326/0003-4819-69-3-529
Download citation file:
Published: Ann Intern Med. 1968;69(3):529-536.
Cardiology, Coronary Heart Disease, Coronary Risk Factors, Smoking.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only