JOHN B. VANDER, M.D., F.A.C.P.; EUGENE A. GASTON, M.D.; THOMAS R. DAWBER, M.D., F.A.C.P.
VANDER JB, GASTON EA, DAWBER TR. The Significance of Nontoxic Thyroid Nodules: Final Report of a 15-Year Study of the Incidence of Thyroid Malignancy. Ann Intern Med. 1968;69:537-540. doi: 10.7326/0003-4819-69-3-537
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Published: Ann Intern Med. 1968;69(3):537-540.
In a total population of 5,127 persons, 218 were found to have nontoxic thyroid nodules, representing 4.2% of the sample—6.4% in females and 1.5% in males.
These lesions were followed for a period of approximately 15 years, and none showed evidence of malignancy at the end of that time.
During the 15-year period of observation, 67 new lesions were detected in persons previously found to be free of thyroid disease. This represented a 15-year incidence rate of 1.4%, 1.7% in females and 0.9% in males. None of these newly detected lesions showed evidence of malignancy.
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Endocrine and Metabolism, Hematology/Oncology, Thyroid Disorders, Endocrine Cancer.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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