MAX HARRY WEIL, M.D., PH.D., F.A.C.P.; HERBERT SHUBIN, M.D., F.A.C.P.
WEIL M., SHUBIN H.; Isoproterenol for the Treatment of Circulatory Shock. Ann Intern Med. 1969;70:638-641. doi: 10.7326/0003-4819-70-3-638
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Published: Ann Intern Med. 1969;70(3):638-641.
Limitation in cardiac competence as a determinant of survival after the onset of circulatory shock has been the subject of important experimental and clinical studies in recent years (1-3). A fundamental although not exclusive defect in shock due to various causes is a significant reduction in cardiac output. Yet when shock occurs in patients who have hepatic cirrhosis or generalized peritonitis, large arteriovenous shunts often account for normal or even increased cardiac output values (4, 5). The portion of the cardiac output that bypasses the capillary exchange circuit does not serve metabolic needs. If the portion available for tissue perfusion
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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