JAMES G. HILTON, M.D.
HILTON JG. ALDOSTERONISM AND SPIRONOLACTONE. Ann Intern Med. 1969;70:648-649. doi: 10.7326/0003-4819-70-3-648
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Published: Ann Intern Med. 1969;70(3):648-649.
To the Editor: I was very interested in the article entitled "Aldosteronism in Hypertension: The Response to Spironolactone" by Spark and Melby (Ann. Intern. Med. 69: 685, 1968). What particularly struck me was the fact that in the patients with primary aldosteronism, treated with spironolactone, the blood pressures fell to normal, while the low plasma renin activity rose to values comparable with those seen in the group of patients with hypertension and secondary aldosteronism. I would suspect that the reason the blood pressures remained normal despite increased renin levels lies in the fact that these patients were in negative sodium
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