R. C. Dickson, M.D., F.A.C.P.; C. N. Williams, M.R.C.S., L.R.C.P.
Dickson RC, Williams CN. Bile Salt Diarrhea.. Ann Intern Med. 1969;70:1066. doi: 10.7326/0003-4819-70-5-1066_3
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Published: Ann Intern Med. 1969;70(5):1066.
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Recent advances in knowledge of bile salt metabolism have shown them to have a cathartic action on the colon. Normally these salts are reabsorbed in the terminal ileum. It has therefore been postulated that the severe diarrhea occasionally seen after terminal ileum resection may be related to this mechanism, the severity of the diarrhea being proportional to the extent of the resection.
To test this hypothesis we studied six patients with incapacitating diarrhea. All had undergone ileal resection some years previously and had had repeated investigations for the cause of the diarrhea without success. These patients were placed on a
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