Joseph W. Linhart, M.D.; Frank J. Hildner, M.D.; S. Serge Barold, M.D.; Philip Samet, M.D.
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Although recent investigations have elucidated most of the mechanisms of action of nitroglycerine, its effect upon left ventricular myocardial function is still not clear. Therefore, left ventricular function was determined during left heart catheterization before and after 0.4 to 0.6 mg nitroglycerin, sublingually, in 23 patients (18 men and 5 women) ranging in age from 41 to 68 years (mean, 54). Left ventricular function curves, relating stroke work to end-diastolic pressure, were constructed using a graded infusion of angiotensin to augment afterload. Sixteen of the 23 patients were shown to have significant coronary artery disease by cineangiography.
Nitroglycerin produced a
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Linhart JW, Hildner FJ, Barold SS, Samet P. The Effect of Sublingual Nitroglycerin Upon Left Ventricular Myocardial Function.. Ann Intern Med. 1969;70:1079. doi: 10.7326/0003-4819-70-5-1079_1
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Published: Ann Intern Med. 1969;70(5):1079.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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