Zbigniew A. Zawadzki, M.D.; George A. Edwards, M.D., F.A.C.P.
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A 42-year-old white man with a beta-spike deformity of the serum electrophoretic pattern and severe iron deficiency initially was thought to have paraproteinemia, but by immunochemical and radioautographic means the apparent M protein was identified as transferrin. Serial observations of the patient's serum were made as the iron deficiency was being corrected. Also, 10 iron-deficient men and 10 women in the third trimester of pregnancy (conditions characterized by hypertransferrinemia) were studied. In each subject electrophoresis and immunoelectrophoresis of serum proteins were performed, the levels of serum iron and total iron-binding capacity were determined, and the concentration of serum transferrin was
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Zawadzki ZA, Edwards GA. Hypertransferrinemia Simulating Paraproteinemia.. Ann Intern Med. 1969;70:1105. doi: 10.7326/0003-4819-70-5-1105_1
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Published: Ann Intern Med. 1969;70(5):1105.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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