Melvin L. Reed, M.D.; V. K. Vaitkevicius, M.D., F.A.C.P.; Clarence B. Vaughn, M.D.
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Systemic 5-fluorouracil (5-FU) therapy of gastroitestinal tumors produces objective tumor remissions in 12 to 20% of patients. Drug toxicity prevents administration of sufficient amounts of 5-FU to induce higher regression rates. With tuomrs limited to the liver, systemic therapy can be avoided. The liver receives a double blood supply, approximately 90 to 95% from the portal vein and 5 to 10% from the hepatic artery. Primary or metastatic tumor in the liver receives approximately 5 to 10% from the portal vein and 90 to 95% from the hepatic artery. Infusion of cytotoxic drugs directly into the hepatic artery delivers all
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Reed ML, Vaitkevicius VK, Vaughn CB. Chronic Hepatic Artery Infusion Therapy of Primary and Metastatic Hepatic Malignancies.. Ann Intern Med. 1969;70:1106. doi: 10.7326/0003-4819-70-5-1106_1
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Published: Ann Intern Med. 1969;70(5):1106.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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