ROGER K. LARSON, M.D., F.A.C.P.; MARTIN L. BARMAN, M.D.; FRIEDRICH KUEPPERS, M.D.; H. HUGH FUDENBERG, M.D.
LARSON RK, BARMAN ML, KUEPPERS F, FUDENBERG HH. Genetic and Environmental Determinants of Chronic Obstructive Pulmonary Disease. Ann Intern Med. 1970;72:627-631. doi: 10.7326/0003-4819-72-5-627
Download citation file:
Published: Ann Intern Med. 1970;72(5):627-631.
The prevalence of abnormalities of pulmonary function among 156 relatives of 61 patients with chronic obstructive pulmonary disease was found to be significantly higher than the prevalence in a control group of their spouses. No relationship of this increased familial prevalence to alpha1-antitrypsin deficiency could be demonstrated. This provides further evidence that at least some chronic obstructive pulmonary disease may be genetically determined and that this may be independent of alpha1-antitrypsin deficiency. Heredity and smoking probably contribute about equally to the likelihood of developing chronic obstructive pulmonary disease.
Learn more about subscription options.
Register Now for a free account.
Pulmonary/Critical Care, Chronic Obstructive Airway Disease.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only