H. JUERGEN NORD, M.D.; ARTURO L. FONTANES, M.D.; JOHN F. WILLIAMS, MD., F.A.C.P.
The effectiveness of glucagon, 5 mg, subcutaneously, every 4 hr or 1 or 4 mg/hr by intravenous infusion, in the treatment of congestive heart failure was determined in 18 patients. Duration of therapy was 96 hr in 11 patients and 4 to 84 hr in the rest. Seven patients improved during glucagon administration whereas eight were unaffected and three became worse. The most favorable response occurred in patients suffering their first episode of heart failure. Only one of four patients with heart failure previously unresponsive to vigorous therapeutic measures improved. With the exception of the three patients in this latter group, all who did not improve with glucagon subsequently responded well to digitalis, diuretics, or both. Nausea and vomiting occurred in the majority and necessitated discontinuing glucagon treatment in five. Glucagon appears to have limited usefulness in the treatment of most patients with congestive heart failure.
Learn more about subscription options.
Register Now for a free account.
NORD HJ, FONTANES AL, WILLIAMS JF. Treatment of Congestive Heart Failure with Glucagon. Ann Intern Med. 1970;72:649-653. doi: 10.7326/0003-4819-72-5-649
Download citation file:
Published: Ann Intern Med. 1970;72(5):649-653.
Cardiology, Heart Failure.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only