D. SCOTT NICKERSON, B.S.; RALPH C. WILLIAMS, M.D.; MARGARET BOXMEYER, B.S.; PAUL G. QUIE, M.D.
NICKERSON DS, WILLIAMS RC, BOXMEYER M, QUIE PG. Increased Opsonic Capacity of Serum in Chronic Heroin Addiction. Ann Intern Med. 1970;72:671-677. doi: 10.7326/0003-4819-72-5-671
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Published: Ann Intern Med. 1970;72(5):671-677.
Studies of phagocytosis promoting capacity and immunoglobulin levels were conducted in a group of 25 long-term heroin addicts. Sera were collected from addicts at Lexington, Ky.; Synanon House, San Francisco; and Albuquerque, N. M. Striking increments in heat-stable opsonins for Escherichia coli and Serratia marcescens were found in many addicts' sera as compared with normal control sera. Marked elevations of gamma M (up to 660 mg/100 ml) were found in many sera, accompanied by 19S antibacterial opsonins as demonstrated by separations in sucrose density gradients. Antigamma-globulin factors were present in 36% of the addicts studied. There was no impairment in ingestion or killing of test bacteria by polymorphonuclear leukocytes obtained from subjects on substitution narcotic therapy.
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Tobacco, Alcohol, and Other Substance Abuse.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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