L. M. Morrison, M.D., F.A.C.P.; J. J. Quilligan Jr., M.D.; K. Murata, M.D.; G. S. Bajwa, D.V.M.; S. Bernick, Ph.D.; P. G. Rucker, M.A.; L. Freeman, Ph.D.; B. H. Ershoff, Ph.D.
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Three acid mucopolysaccharides—heparin, chondroitin sulfate A and chondroitin sulfate C were tested for effectiveness against coronary and aortic atherosclerosis. Chondroitin sulfate A was found to be antiatherogenic in a series of monkeys, rats and rabbits; chondroitin sulfate C was found to be antiatherogenic in the two species tested, rats and rabbits. Heparin was not found to be antiatherogenic in monkeys. Chrondroitin sulfate A and C and heparin were found to be antithrombogenic in a series of dogs and rabbits, while chondroitin sulfate A and C were found to be orally both antiatherogenic and antithrombogenic in six consecutive experiments with rats.
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Morrison LM, Quilligan JJ, Murata K, Bajwa GS, Bernick S, Rucker PG, et al. Prevention of Ischemic Heart Disease by Acid Mucopolysaccharides.. Ann Intern Med. 1970;72:786. doi: 10.7326/0003-4819-72-5-786_2
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Published: Ann Intern Med. 1970;72(5):786.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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