Allan D. Thomson, M.D.; Herman Baker, Ph.D.; Carroll M. Leevy, M.D., F.A.C.P.
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Malabsorption of commercially available thiamine preparations is often responsible for clinical and laboratory evidence of a deficiency of this vitamin. Studies of thiamine propyl disulfide indicate its intestinal transport, unlike thiamine hydrochloride which is widely used as a food supplement, is not rate-limited. Absorption of these congeners was compared in 10 healthy volunteers and 10 malnourished alcoholics with normal blood (25 to 70 ng/ml) and spinal fluid (25 to 40 ng/ml) thiamine levels (Ochromonas danica). Therapeutic effectiveness of thiamine hydrochloride and thiamine propyldisulfide was investigated in eight alcoholics with Wernicke's encephalopathy and oculomotor palsy who had an average blood and
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Thomson AD, Baker H, Leevy CM. Correction of Thiamine Depletion Syndromes Refractory to Oral Thiamine Hydrochloride.. Ann Intern Med. 1970;72:792. doi: 10.7326/0003-4819-72-5-792_1
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Published: Ann Intern Med. 1970;72(5):792.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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