Sidney Cohen, M.D.; William Lipshutz, M.D.
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Medical treatment for symptomatic gastroesophageal reflux and peptic esophagitis consists of reducing gastric acidity and reducing gastroesophageal reflux. Anticholinergic medications are effective in diminishing acid secretion, but their effect on lower esophageal sphincter competence, the prime barrier to prevention of reflux, is conflicting. The present study was designed to determine whether anticholinergic medications affect  resting lower esophageal sphincter competence,  intrinsic adaptive changes in the sphincter competence to changes in intra-abdominal pressure, and  adaptive changes in sphincter competence to endogenous gastrin release. Lower esophageal sphincter pressure measurements using an infused open-tipped recording system were made in 20 normal
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Cohen S, Lipshutz W. Anticholinergic Therapy: A Triple Threat to Lower Esophageal Sphincter Competence.. Ann Intern Med. 1970;72:792. doi: 10.7326/0003-4819-72-5-792_3
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Published: Ann Intern Med. 1970;72(5):792.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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