Pauline Bazinet, M.D.; Paul Krasner, M.D.; Serge Duckett, M.D.; Norman Lasker, M.D., F.A.C.P.
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Renal involvement in osteo-onychodysplasia (nail-patella syndrome) has been well delineated. A family consisting of the father and his three daughters was investigated. The father presented with renal insufficiency (creatinine clearance, 10 ml/min) and proteinuria; the daughters were found to have 0 to 1 + proteinuria with normal creatinine clearance. Inulin and para-amino hippuric acid clearances were normal in the three daughters, whereas all showed a concentration defect with normal urinary acidification.
No abnormality could be found in amino acid excretion, but 24-hr urine levels of hydroxyproline were elevated. Findings on light microscopy in the early stages included local proliferative changes
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Bazinet P, Krasner P, Duckett S, Lasker N. Renal Abnormality in the Nail-Patella Syndrome.. Ann Intern Med. 1970;72:804. doi: 10.7326/0003-4819-72-5-804_4
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Published: Ann Intern Med. 1970;72(5):804.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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