Neal J. Weinreb, M.D.; Rosamond Janis, M.D.; K. P. Eshwar, M.D.; Edward Weinstein, M.D.; Richard Hays, M.D.
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The Fanconi syndrome in adults is generally associated with multiple myeloma, amyloidosis, hyperglobulinemia, and nephrotoxic metals and drugs. This report described a generalized defect in proximal tubular function in a nephrotic patient with membranous glomerulonephritis. A 65-year-old man was admitted with an 8-year history of mild proteinuria and a 3-month history of edema progressing to anasarca. He had heavy proteinuria (8 to 9 g/day), hypoalbuminemia (1.2 g/100 ml), and renal insufficiency (creatinine clearance, 16 ml/min). In addition, he was found to have renal glycosuria (urine glucose, 6 g/liter with serum glucose 95 and 100 mg/100 ml) and aminoaciduria, with significantly
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Weinreb NJ, Janis R, Eshwar KP, Weinstein E, Hays R. Renal Glycosuria, Aminoaciduria, and Proximal Renal Tubular Acidosis in Association with Membranous Glomerulonephritis.. Ann Intern Med. 1970;72:805. doi: 10.7326/0003-4819-72-5-805_3
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Published: Ann Intern Med. 1970;72(5):805.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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