Mark C. Levine, M.D., (Associate); Jack R. Grommons, M.D.
This content is PDF only. Please click on the PDF icon to access.
An unusual disorder of unknown cause, characterized by continuous muscle fasciculation and myotonia in otherwise normal young men, was first described by Isaacs in 1961; a total of five cases have been reported. Other than electromyographic evidence of continuous motor unit firing, all biochemical and neurodiagnostic studies have been normal, and symptoms have responded dramatically to therapy with diphenylhydantoin.
A patient with a similar clinical picture whose muscular twitchings and stiffness have been controlled by diphenylhydantoin for over 5 years is presented. Extensive investigations (including serum electrolytes, calcium, magnesium, enzymes, cholinesterase, muscle biopsy, cerebrospinal fluid analysis, electroencephalogram, and X rays)
Learn more about subscription options.
Register Now for a free account.
Levine MC, Grommons JR. The Syndrome of Continuous Muscle Fiber Activity.. Ann Intern Med. 1970;72:807. doi: 10.7326/0003-4819-72-5-807_3
Download citation file:
Published: Ann Intern Med. 1970;72(5):807.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only