JACK LIEBERMAN, M.D.; CHARLES MITTMAN, M.D.
Screening to detect heterozygous alpha1-antitrypsin deficiency was done in 400 acutely and chronically ill patients without pulmonary disease. Electrophoresis of serum proteins on cellulose-acetate membranes was followed by an enzymatic assay of inhibitor on those sera with less than 0.25 g/100 ml alpha1-globulin. Forty-eight patients had gross electrophoretic abnormalities of gamma globulin, alpha2-globulin, or of total protein content with normal alpha1globulin or antitrypsin activity. This included all patients with nephrosis and cirrhosis. Seventeen patients had antitrypsin levels in the heterozygous range, and nine of these had a disease that could potentially affect protein metabolism. Adequate family studies performed in six of these nine patients substantiated the heterozygous state. No other protein abnormalities or disease states have been found to produce falsely low antitrypsin levels. The method does not falsely identify normal individuals as heterozygotes when other gross serum protein abnormalities exist.
Learn more about subscription options.
Register Now for a free account.
LIEBERMAN J, MITTMAN C. Screening for Heterozygous Alpha1-Antitrypsin Deficiency: II. Effect of Other Serum Protein Abnormalities. Ann Intern Med. 1970;73:9–13. doi: 10.7326/0003-4819-73-1-9
Download citation file:
Published: Ann Intern Med. 1970;73(1):9-13.
Gastroenterology/Hepatology, Liver Disease, Nephrology, Nephrotic Syndrome, Pulmonary/Critical Care.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only