GARY B. WEISS; JOEL MOSS
To the editor: An interesting biochemical possibility is suggested by Dr. Omenn's report (Ann Intern Med 72:136-138, 1970) on the ectopic synthesis of polypeptide hormones by tumors. Dr. Omenn postulates that steroids and thyroxine are not synthesized by ectopic foci because of the complexity of the enzyme systems involved in their production. Similarly, proinsulin may be released by some of these tumors, rather than insulin, because of the absence of converting enzymes (1). In view of recent findings by Gevers, Kleinkauf, and Lipmann (2) and Bredesen, Zimmer, and Laland (3) that the cyclic decapeptide antibiotic, gramicidin S, is synthesized by
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WEISS GB, MOSS J. Mechanisms of Polypeptide Hormone Synthesis. Ann Intern Med. 1970;73:492–493. doi: 10.7326/0003-4819-73-3-492_3
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Published: Ann Intern Med. 1970;73(3):492-493.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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