J. HORTON, M.B., Ch.B., F.A.C.P.; K. B. OLSON, M.D., F.A.C.P.; J. SULLIVAN, M.D.; C. REILLY, M.D.; B. SHNIDER, M.D., F.A.C.P.; THE EASTERN COOPERATIVE ONCOLOGY GROUP
HORTON J, OLSON KB, SULLIVAN J, REILLY C, SHNIDER B, THE EASTERN COOPERATIVE ONCOLOGY GROUP. 5-Fluorouracil in Cancer: An Improved Regimen. Ann Intern Med. 1970;73:897-900. doi: 10.7326/0003-4819-73-6-897
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Published: Ann Intern Med. 1970;73(6):897-900.
Fluorouracil is a palliative antitumor agent whose use is limited by toxicity. Methods for reducing toxicity have been described, but the package insert still recommends a course of daily injections for hospital-confined patients. Such a course, in our hands, has previously resulted in severe morbidity and 14% to 16% mortality. This study compared intravenous doses of 7.5, 15, and 20 mg/kg ideal weight given undiluted at weekly intervals without a loading course to 201 patients with advanced cancer. Toxicity was mild at 7.5 mg/kg and 15 mg/kg ideal weight. It was more marked at 20 mg/kg ideal weight, and two patients died of drug toxicity. The occurrence of tumor shrinkage of more than 50% at doses of 7.5, 15, and 20 mg/kg ideal weight was 5%, 20%, and 25%, respectively. Additional patients had tumor shrinkage of less than 50% or stabilization of disease. Remissions were associated with symptomatic benefit and increased survival. A weekly intravenous injection of fluorouracil, 15 mg/kg ideal weight, without a loading course was a well-tolerated regimen that could be given safely to outpatients. Objective tumor regressions were produced as frequently on this regimen as from the currently recommended course.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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