GERALD MARSCHKE, M.D.; ARTHUR SARAUW, M.D.
MARSCHKE G, SARAUW A. Polymyxin Inhalation Therapeutic Hazard. Ann Intern Med. 1971;74:144-145. doi: 10.7326/0003-4819-74-1-144
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Published: Ann Intern Med. 1971;74(1):144-145.
To the editor: Pseudomonas infection in the chronic pulmonary patient is difficult to treat. Attempting to concentrate the antibiotic at the infection site, we have given polymyxin B sulfate by aerosol, with little therapeutic success. Moreover, two patients developed respiratory distress, and their cases are the basis of this report.
Patient L.M., a 51-year-old woman with bronchiectasis, entered the hospital 16 February 1965 because of cough, breathlessness, and purulent sputum. Despite treatment with several antibiotics, including injected polymyxin B, Pseudomonas aeruginosa persisted in her sputum. Inhalation therapy, consisting of isoproterenol solution administered with a De Vilbiss nebulizer and an air
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