MURRILL M. SZUCS, M.D.; HAROLD L. BROOKS, M.D.; WILLIAM GROSSMAN, M.D.; JOHN S. BANAS, M.D.; STEVEN G. MEISTER, M.D.; LEWIS DEXTER, M.D., F.A.C.P.; JAMES E. DALEN, M.D.
SZUCS MM, BROOKS HL, GROSSMAN W, BANAS JS, MEISTER SG, DEXTER L, et al. Diagnostic Sensitivity of Laboratory Findings in Acute Pulmonary Embolism. Ann Intern Med. 1971;74:161-166. doi: 10.7326/0003-4819-74-2-161
Download citation file:
Published: Ann Intern Med. 1971;74(2):161-166.
Many different laboratory tests have been used to screen patients for pulmonary embolism. The sensitivity of certain laboratory tests was assessed in a prospective study of 50 patients with angiographically documented acute pulmonary embolism. Electrocardiographic evidence of right heart strain occurred in only nine patients; each had massive pulmonary embolism. Nonspecific chest X-ray abnormalities (infiltrate, effusion, or elevated diaphragm) occurred in 71%; 29% had a normal chest X ray. Lactic dehydrogenase (LDH) was increased in 83% of the patients, but serum glutamic-oxalacetic transaminase (SGOT) and bilirubin were of little value. The triad of increased LDH, normal SGOT, and increased bilirubin occurred in only 12%. Lung scans performed in 24 patients were abnormal. Arterial Po2 (breathing room air) was decreased (≤ 80 mm Hg) in all 36 patients tested. Arterial Po2 and lung scan are the most sensitive tests for screening; if either is normal, acute pulmonary embolism is essentially excluded.
Learn more about subscription options.
Register Now for a free account.
Emergency Medicine, Pulmonary/Critical Care, Venous Thromboembolism, Pulmonary Embolism.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only