Joseph M. Cardamone, M.D.; J. Roger Edson, M.D.; James R. McArthur, M.D.; Harry S. Jacob, M.D.
This content is PDF only. Please click on the PDF icon to access.
A hemorrhagic diathesis frequently complicates myeloproliferative disorders, yet its pathogenesis remains enigmatic. The frequency of abnormalities in platelet morphology in these disorders suggests platelet malfunction might underlie this defective hemostasis. Platelet function tests were performed on 21 consecutive patients with various myeloproliferative disorders (polycythemia vera, myelogenous leukemia, myelofibrosis, and erythroleukemia). Tests included platelet adhesiveness (Salzmann), factor 3 release (Russel's viper venom method), agregation induced by adenosine diphosphate, collagen and catechols, and Ivy bleeding time. All 21 patients demonstrated at least one platelet dysfunction. Multiple abnormalities correlated with increasing clinical severity of the hemorrhagic diathesis. Platelet aggregation was most often abnormal:
Learn more about subscription options.
Register Now for a free account.
Cardamone JM, Edson JR, McArthur JR, Jacob HS. Abnormal Platelet Function in the Myeloproliferative Disorders.. Ann Intern Med. 1971;74:826. doi: 10.7326/0003-4819-74-5-826_3
Download citation file:
Published: Ann Intern Med. 1971;74(5):826.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only