J. M. Martinez, M.D.; S. S. Shapiro, M.D.
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Simultaneous studies of the metabolism of 125I-prothrombin and 131I-fibrinogen were performed in seven patients with thrombocytosis associated with myeloproliferative states. Platelet counts ranged from 600,000 to 3,000,000/mm3. The mean fractional catabolic rate of prothrombin was 60% of the plasma pool per day, a significant increase over the normal mean rate of 42.5% (P < 0.01) The mean fractional catabolic rate of fibrinogen was 34%, significantly increased over the normal mean of 24% (P < 0.01). Correlation between the increased rates of fibrinogen and prothrombin was excellent. Fractional catabolic rates returned to normal in two patients restudied after busulfan treatment restored
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Martinez JM, Shapiro SS. Coagulation Protein Turnover in Patients with Thrombocytosis.. Ann Intern Med. 1971;74:827. doi: 10.7326/0003-4819-74-5-827_3
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Published: Ann Intern Med. 1971;74(5):827.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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