Nathaniel F. Pierce, M.D., F.A.C.P.
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The present whole-cell cholera vaccine stimulates only antibacterial antibodies and provides limited protection of brief duration. Since the effects of cholera are produced by a protein enterotoxin, it is possible that antitoxic immunity might provide an additional and perhaps more effective means of protection. The protective value of antitoxic immunity was evaluated in a canine model of the disease. Dogs were immunized parenterally with highly purified cholera entertoxin plus adjuvant and given a booster after 28 days. High serum antitoxin titers developed and persisted at 10 times preimmunization values for more than 300 days. Serum vibriocidal antibody titers did not
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Pierce NF. Antitoxic Immunity to Cholera.. Ann Intern Med. 1971;74:828. doi: 10.7326/0003-4819-74-5-828_5
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Published: Ann Intern Med. 1971;74(5):828.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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