William J. Mroczek, M.D.; Michael Davidov, M.D.; Frank A. Finnerty Jr., M.D.
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The exaggerated natriuresis and diuresis of hypertensive patients to a hypertonic saline infusion was investigated to determine the importance of the beta adrenergic nervous system and cardiac hemodynamics. Six hypertensive and four normotensive patients received a hypertonic saline load (100 ml of 5% saline/m2 body surface area) before and after beta adrenergic blockade. During the 3 hr after the hypertonic saline loading the hypertensive patients excreted 79% (129 of 158 mEq Na), and the normotensive patients excreted 37% (60 of 162 mEq Na) of the load; whereas after 2 weeks of oral propranolol (120 to 340 mg daily), the hypertensive
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Mroczek WJ, Davidov M, Finnerty FA. The Effect of Beta Adrenergic Blockade on the Exaggerated Natriuresis and Diuresis of Hypertensive Patients.. Ann Intern Med. 1971;74:832. doi: 10.7326/0003-4819-74-5-832_1
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Published: Ann Intern Med. 1971;74(5):832.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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