Eugene I. Winkelman, M.D., F.A.C.P.; Charles H. Brown, M.D., F.A.C.P.; Edgar Achkar, M.D.
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Chronic active hepatitis is defined as active fiver disease persistent or intermittent for more than 3 months and characterized by high levels of serum transaminase; hypergammaglobulinemia; the presence of serum autoantibodies; and histological changes of "piece-meal necrosis," hepatocellular necrosis, and lymphocytic infiltration with various degrees of fibrosis.
The clinical courses (4 months to 4 years) of 18 patients with chronic active hepatitis treated with azathioprine and prednisone are reported. The median age was 22 (15 to 62 years), and 14 patients were women. Fifteen patients had pretreatment biopsies. Initial treatment was 100 mg of azathioprine combined with 20 to 40
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Winkelman EI, Brown CH, Achkar E. Results of Treatment of Chronic Active Hepatitis with Azathioprine and Prednisone.. Ann Intern Med. 1971;74:835. doi: 10.7326/0003-4819-74-5-835_4
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Published: Ann Intern Med. 1971;74(5):835.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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