RICHARD J. DUMA, M.D., F.A.C.P.; WILLIAM I. ROSENBLUM, M.D.; READ F. MCGEHEE, M.D.; MURIEL M. JONES, M.S.; E. CLIFFORD NELSON, SC.D
Two new cases of primary amoebic meningoencephalitis and two previously reported cases are presented as the basis for a description of the clinical, pathological, epidemiological, and protozoological aspects of this infection. The patients acquired their illnesses from swimming in fresh water; the infections were culturally proved to be caused by free-living amoeboflagellates of the genus Naegleria. The infections were rapidly fatal, but in two cases the responsible pathogens were markedly inhibited in vivo (as well as in vitro) by amphotericin B; at present this drug appears to be the only promising treatment available for an otherwise fatal disease.
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DUMA RJ, ROSENBLUM WI, MCGEHEE RF, JONES MM, NELSON EC. Primary Amoebic Meningoencephalitis Caused by Naegleria: Two New Cases, Response to Amphotericin B, and a Review. Ann Intern Med. 1971;74:923-931. doi: 10.7326/0003-4819-74-6-923
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Published: Ann Intern Med. 1971;74(6):923-931.
CNS Infections, Infectious Disease, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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