THOMAS A. MEDSGER, M.D.; ALFONSE T. MASI, M.D., Dr. P.H., F.A.C.P.; GERALD P. RODNAN, M.D., F.A.C.P.; THOMAS G. BENEDEK, M.D., F.A.C.P.; HARRY ROBINSON, D.Sc.
This study was supported in part by grants AM-12049 and AM-05055 of the National Institutes of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.; a grant from the Scleroderma Society of the Arthritis Foundation, New York, N.Y.; grant RR-56 from the General Clinical Research Center; and by the RGK Foundation.
▸Requests for reprints should be addressed to Thomas A. Medsger, Jr., M.D., 985 Scaife Hall, University of Pittsburgh School of Medicine, Pittsburgh, Pa. 15213
MEDSGER TA, MASI AT, RODNAN GP, BENEDEK TG, ROBINSON H. Survival with Systemic Sclerosis (Scleroderma): A Life-Table Analysis of Clinical and Demographic Factors in 309 Patients. Ann Intern Med. 1971;75:369-376. doi: 10.7326/0003-4819-75-3-369
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Published: Ann Intern Med. 1971;75(3):369-376.
A life-table analysis of survivorship with scleroderma was done, using 223 patients diagnosed in Pittsburgh, Pennsylvania, and 86 patients in Memphis, Tennessee. The demographic and clinical characteristics of the two series were similar, thus allowing for both comparison of the two groups and analysis of the total 309 patients. A follow-up during 1970 was successful in 94% of all patients. No difference in survival was found between the two patient groups, the combined 7-year cumulative survivorship being 35%. Significantly decreased survival was found in older patients of both series after allowance was made for the natural increase of mortality with age. Males had significantly worse survival than females. Negroes had significantly worse survival than whites during the first year of follow-up of all patients. When no internal organ involvement was detected at entry to study, the negro prognosis was significantly worse throughout a 7-year follow-up period. Renal, cardiac, and pulmonary involvement were each independently correlated with decreased survival.
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