NORMAN H. SIEGEL, M.D.; ERNEST BEUTLER, M.D.
An 18-year-old man of Irish ancestry was found to have hemolytic anemia associated with a deficiency of red-cell glucose-6-phosphate dehydrogenase. Characterization of the partially purified enzyme showed it to differ from previously described variants. It was electrophoretically slow, showed decreased activity with deamino nicotinamide-adenine dinucleotide phosphate (NADP), and was stable to heat. The abnormal enzyme has been named G-6-PD Carswell.
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SIEGEL NH, BEUTLER E. Hemolytic Anemia Caused by G-6-PD Carswell, A New Variant. Ann Intern Med. 1971;75:437–439. doi: 10.7326/0003-4819-75-3-437
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Published: Ann Intern Med. 1971;75(3):437-439.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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