W. EUGENE SANDERS, M.D.
In 1819 Brentonneau carefully described diphtheria and concluded that the disease was communicable. In 1884 Loffler confirmed that a bacillus was the long-sought etiologic agent of the disease. In 1889 Roux and Yersin identified a soluble toxin that was responsible for the distinctive clinical features of diphtheria. In 1890 Fraenkel prepared an attenuated vaccine, and Behring characterized the specific antitoxin. At the turn of the century, commercial antitoxin was widely used in therapy. In 1913 Behring reported the successful immunization of children against diphtheria, and the Schick test was proved useful in identifying nonimmune individuals. In 1928 Park demonstrated that
Learn more about subscription options.
Register Now for a free account.
SANDERS WE. Diphtheria: "From Miasmas to Molecules" Revisited. Ann Intern Med. 1971;75:639–640. doi: 10.7326/0003-4819-75-4-639
Download citation file:
Published: Ann Intern Med. 1971;75(4):639-640.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only