PHILIP E. CRYER, M.D.; JONAS SODE, M.D.
Twenty-four-hour urinary 17-hydroxycorticoids, free 11-hydroxycorticoids, 17-ketosteroids, and catecholamines were measured repetitively in a volunteer subject during control and base-line periods and during the short-term ingestion of relatively small doses of commonly used analgesic and tranquilizer-sedative drugs. The ingestion of propoxyphene, 65 mg, three times daily, was associated with significant depression of the urinary 17-hydroxycorticoids and 17-ketosteroids; significant depression of the 17-hydroxycorticoids and free 11-hydroxycorticoids occurred during the ingestion of pentazocine, 50 mg, twice daily. In the dosages used, the short-term ingestion of acetylsalicylic acid, acetaminophen, chlordiazepoxide, diazepam, phenobarbital, or diphenhydramine did not interfere with the measurement of 17-hydroxycorticoids, free 11-hydroxycorticoids, or 17-ketosteroids in the urine. None of the drugs tested interfered with the measurement of urinary catecholamines, norepinephrine, or epinephrine.
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CRYER PE, SODE J. Drug Interference with Measurement of Adrenal Hormones in Urine: Analgesics and Tranquilizer-Sedatives. Ann Intern Med. 1971;75:697–702. doi: 10.7326/0003-4819-75-5-697
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Published: Ann Intern Med. 1971;75(5):697-702.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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