E. BOURKE, M.D.; G. FRINDT, M.D.; PAULINE FLYNN, B.A.; G. E. SCHREINER, M.D., F.A.C.P.
A 10-year-old girl with primary hyperoxaluria, calcium oxalate nephrolithiasis, and normal blood urea was studied. Despite high urinary oxalate and glycolate excretion, normal activity of α-ketoglutarate:glyoxylate carboligase was observed in both mitochondria-containing and soluble cytoplasmic fractions of striated muscle tissue. No effect on the urinary excretion of oxalate or glycolate was observed with the administration of pyridoxine, allopurinol, or calcium carbimide. A 40% reduction in urinary oxalate excretion was produced by isocarboxazid therapy. Further studies are necessary to elucidate the role of monoamine oxidase inhibitors in the treatment of primary hyperoxaluria.
Learn more about subscription options.
Register Now for a free account.
BOURKE E, FRINDT G, FLYNN P, SCHREINER GE. Primary Hyperoxaluria with Normal Alpha-Ketoglutarate:Glyoxylate Carboligase Activity: Treatment with Isocarboxazid. Ann Intern Med. 1972;76:279–284. doi: 10.7326/0003-4819-76-2-279
Download citation file:
Published: Ann Intern Med. 1972;76(2):279-284.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only