B. J. KENNEDY, MD., F.A.C.P.; ATHANASIOS THEOLOGIDES, M.D., PH.D., F.A.C.P.
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The combination of several drug agents for the treatment of malignant diseases represents a new era in the chemotherapy of cancer and emphasizes that cure of some neoplastic diseases is a potentially attainable goal. In Hodgkin's disease, lymphoma, acute leukemia, and breast cancer, combination drug therapy has made possible a higher rate of regression (tumor shrinkage) and, more important, a higher rate of complete remission (disappearance of measurable tumor). As a result, combination chemotherapy is being endorsed by clinicians. This mode of therapy has been accepted, however, for many malignant neoplasms without adequately controlled studies.
Historically, the first phase of
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KENNEDY BJ, THEOLOGIDES A. Controls in Cancer Chemotherapy. Ann Intern Med. 1972;76:321–322. doi: 10.7326/0003-4819-76-2-321
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Published: Ann Intern Med. 1972;76(2):321-322.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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