CHARLES E. CHERUBIN, M.D., F.A.C.P.; SETH KANE, B.A.; DANIEL R. WEINBERGER, B.A.; ELLIOT WOLFE, M.D.; THOMAS MCGINN, M.D.
CHERUBIN CE, KANE S, WEINBERGER DR, WOLFE E, MCGINN T. Persistence of Transaminase Abnormalities in Former Drug Addicts. Ann Intern Med. 1972;76:385-389. doi: 10.7326/0003-4819-76-3-385
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Published: Ann Intern Med. 1972;76(3):385-389.
A large group of ex-addicts in residence in a rehabilitation program were studied to determine their medical history of hepatitis, the frequency of SH/Au antigen, and the prevalence of liver malfunction. Fifty percent of our population had a history of hepatitis while using drugs. Among the whites, 58.4% had had hepatitis, whereas only 26% of the nonwhites had such a history. The frequency of SH/Au antigen by Ouchterlony technique (1.2/100) was consistent with that of previous studies. There was a significant decline in serum glutamic-pyruvic transaminase (SGPT) values as a function of time free of drug and needle use. There was a 40% frequency of abnormal results (> 50 Karmen units/ml) in tests taken soon after entry into the program; in tests taken after 4 months and up to a year there was a 20% frequency of abnormal results. The persistent abnormal SGPT results and liver biopsy findings in several residents with persistently elevated transaminases showed a high frequency of chronic inflammatory liver disease among the population.
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Tobacco, Alcohol, and Other Substance Abuse.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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