STANLEY ZUCKER, M.D.; C. HAROLD MIELKE, M.D.; JOHN R. DUROCHER, M.D.; WILLIAM H. CROSBY, M.D.
ZUCKER S, MIELKE CH, DUROCHER JR, CROSBY WH. Oozing and Bruising Due to Abnormal Platelet Function (Thrombocytopathia): A Family Study of the Syndrome. Ann Intern Med. 1972;76:725-731. doi: 10.7326/0003-4819-76-5-725
Download citation file:
Published: Ann Intern Med. 1972;76(5):725-731.
This report describes 6 unrelated patients with mild bleeding disorders caused by abnormalities of platelet function. This syndrome has its onset in childhood and has one or more of these characteristics: easy bruising, spontaneous bleeding from mucosal membranes, excessive bleeding after minor or major surgery, and menorrhagia. Coagulation tests in these patients showed a prolonged bleeding time and a delayed and diminished platelet aggregation response to epinephrine and collagen. The platelet count, platelet adhesiveness, platelet factor-3 release, and factor VIII activity were usually normal. Pedigree studies suggested an autosomal-dominant mode of inheritance. An experimental trial of prednisone therapy in five patients resulted in significant improvement in the bleeding time, yet platelet aggregation test results were unaltered.
Learn more about subscription options.
Register Now for a free account.
Emergency Medicine, Hematology/Oncology, Platelet Disorders.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only