STANLEY ZUCKER, M.D.; C. HAROLD MIELKE, M.D.; JOHN R. DUROCHER, M.D.; WILLIAM H. CROSBY, M.D.
This report describes 6 unrelated patients with mild bleeding disorders caused by abnormalities of platelet function. This syndrome has its onset in childhood and has one or more of these characteristics: easy bruising, spontaneous bleeding from mucosal membranes, excessive bleeding after minor or major surgery, and menorrhagia. Coagulation tests in these patients showed a prolonged bleeding time and a delayed and diminished platelet aggregation response to epinephrine and collagen. The platelet count, platelet adhesiveness, platelet factor-3 release, and factor VIII activity were usually normal. Pedigree studies suggested an autosomal-dominant mode of inheritance. An experimental trial of prednisone therapy in five patients resulted in significant improvement in the bleeding time, yet platelet aggregation test results were unaltered.
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ZUCKER S, MIELKE CH, DUROCHER JR, CROSBY WH. Oozing and Bruising Due to Abnormal Platelet Function (Thrombocytopathia): A Family Study of the Syndrome. Ann Intern Med. 1972;76:725-731. doi: 10.7326/0003-4819-76-5-725
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Published: Ann Intern Med. 1972;76(5):725-731.
Emergency Medicine, Hematology/Oncology, Platelet Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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