Martin J. Smith, M.D.; Arne Slungaard
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Normal lymphocytes respond to the presence of allogenic lymphocytes in cultures with a high uptake of 3H-thymidine. We studied the interaction of chronic lymphatic leukemia (CLL) lymphocytes with normal allogenic lymphocytes, using the oneway, mixed leukocyte culture technique of Bach, with Ficoll-Hypaque gradient, to harvest lymphocytes. The lymphocytes of 11 patients with this disease were tested separately against those of 4 unrelated normal control persons. Contamination by nonmononuclear cells was uniformly less than 5%, and viability (eosin dye exclusion) was greater than 90%. In all 11 patients an impaired responsiveness was found. The mean response of CLL lymphocytes to those
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Smith MJ, Slungaard A. The Impaired Responsiveness of Chronic Lymphatic Leukemia (CLL) Lymphocytes to Allogenic Lymphocytes.. Ann Intern Med. 1972;76:871. doi: 10.7326/0003-4819-76-5-871_2
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Published: Ann Intern Med. 1972;76(5):871.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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