J. V. Donadio, M.D., F.A.C.P.; R. D. Wagoner, M.D., F.A.C.P.; R. H. Ferguson, M.D., F.A.C.P.; F. C. McDuffie, M.D., F.A.C.P.; K. E. Holley, M.D.
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It is unclear whether treatment of patients with lupus nephritis with combined corticoid and cytotoxic drugs is more effective than treatment with corticoids alone. Two treatment programs were evaluated for 6 months in patients with active lupus glomerulonephritis. Group A (9 patients) received prednisone (mean, 40 mg/day) and Group B (7 patients) received prednisone (same dosage) and azathioprine (2 to 3 mg/kg body weight-day). Renal biopsy activity was scored by a semiquantitative method based on the presence and extent of glomerular proliferation, necrosis, karyorrhexis, fibrinoid deposition, hyaline thrombi, and vasculitis. According to activity scores patients were randomly assigned to Group
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Donadio JV, Wagoner RD, Ferguson RH, McDuffie FC, Holley KE. Treatment of Patients with Lupus Nephritis with Prednisone and Combined Prednisone-Azathioprine.. Ann Intern Med. 1972;76:873–874. doi: 10.7326/0003-4819-76-5-873_4
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Published: Ann Intern Med. 1972;76(5):873-874.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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